BIOLUMINESCENCE IMAGING (BLI)

The most widely used in vivo imaging technology.

OVERVIEW

  • Bioluminescence Imaging (BLI) is a naturally occurring phenomenon, allowing some species to naturally emit photons (light) through a chemical reaction.
  • Biologists can harness this same type of reaction to study biological processes and diseases in animal models. Over 10,000 papers have been published leveraging this technique in the field of oncology alone.
  • Track primary tumors over time, as well as metastatic lesions.
  • Study cancer progression in organs unreachable by conventional ultrasound, including the brain and lung.

BLI in Action

  • Whole body tissue data is acquired with widefield B-mode ultrasound.
  • The tumor’s anatomical context in the tissue is clearly identified.
  • The microvascular density of the tumor is defined using Acoustic Angiography.
  • The tumor’s volume is precisely determined, despite its abnormal shape.
  • Whole body tissue data is acquired with widefield B-mode ultrasound.
  • The tumor’s anatomical context in the tissue is clearly identified.
  • The microvascular density of the tumor is defined using Acoustic Angiography.
  • The tumor’s volume is precisely determined, despite its abnormal shape.
  • Luc-tagged tumor cells are monitored over time using BLI.
  • This tumor line is identified as non-metastasizing.
  • Ultrasound is then used to accurately measure tumor volume, visualize anatomical context, and tumor microvasculature.

BLI + US. Molecular imaging combined with soft tissue contrast.

Available exclusively on our Strata imaging platform.