Molecular imaging with

The first imaging system of its kind

OVERVIEW

  • The STRATA brings the power of ultrasound and bioluminescence (BLI) imaging together for the first time.
  • Wide-field 3D ultrasound images are captured from below, while BLI is captured from above with a super-cooled CCD camera.
  • Study both anatomical, functional, and molecular signatures of diseases in a single easy-to-use workflow.
  • Evaluate microvasculature with optional Acoustic Angiography contrast-enhanced imaging module.
  • No sonographer required!

STRATA IN ACTION

C-planes reconstructed from 3D volumetric data in mice with subcutaneous tumors (orange arrows).

Same mouse imaged over several weeks. Luc-tagged tumor cells can be seen expanding throughout the abdomen.

Acoustic Angiography used to visualize a tumor’s microvascular supply evolve over time. Scale bar is 1 cm.

Analysis of drug toxicity

Heart detected automatically

Short-axis m-mode

4D echocardiography

  • Cancer therapeutics can induce off-target effects, including cardiotoxicity.
  • Measure left ventricular ejection fraction (EF) and fractional shortening (FS) to evaluate toxicity of candidate drugs.
  • Tumor and cardiac measurements can be performed on the same imaging session without moving the mouse.
  • Never question your cardiac data integrity again with SonoVol’s automated M-mode positioning!
  • Coming soon: non-ECG gated 4D cardiac imaging!