Radiation Research

SonoVol® platform makes it easy to non-invasively image radiation induced changes to tissue.

Our benchtop platform can be deployed next to your irradiator.

  • Get imaging data in near real-time, before and after irradiation timepoints.
  • Fully integrated anesthesia system can be combined with your lab’s existing isoflurane delivery approach, or as standalone solution.

Quantify tumor size non-invasively with excellent soft tissue contrast

  • Biology doesn’t happen in two dimensions – SonoVol® imaging technology enables true volumetric tumor measurements not possible with calipers.
  • Visualize tumors in the context of the broader anatomy with wide-field imaging not possible with conventional hand-held ultrasound
  • No geometrical assumptions + excellent soft tissue contrast = more accurate measurements and smaller error bars.
  • Evaluate both orthotopic and subcutaneous models.
  • Instantiate new models using image-guided injection

Visualize radiation induced microvascular changes over time

Murine brain vasculature imaged with acoustic angiography. Image courtesy of P. Durham (UNC-Chapel Hill)

Tumors imaged over time with Acoustic Angiography

Czernuszewicz, T.J. et al 2018. A new preclinical ultrasound platform for widefield 3D imaging of rodents. Review of Scientific Instruments, 89(7), p.075107. (Pubmed link)

  • Microvasculature and angiogenic changes can reveal response to therapy sooner than tumor size.
  • Using the Acoustic Angiography imaging module from SonoVol®, tumor blood vessel network morphology (BVM) and vessel density (BVD) can be evaluated.

We are excited to announce that SonoVol is now part of PerkinElmer. Learn more.